Toxocariosis and inflammatory joint disease
Keywords:
Toxocara canis, arthritis, zoonotic disease, synovial membrane, interleukin, mast cellAbstract
Toxocariosis is a serious epidemiological problem in many countries; it is a zoonotic disease, humans can become infected by ingestion of Toxocara canis infective eggs, which are found in contaminated soil with canine feces. Diagnosis in humans is complicated, so it is not really taken in consideration as a differential diagnosis in diseases human; however, the presence of this parasitosis has been associated with some chronic inflammatory diseases such as atopy, asthma and arthritis. Hence the importance of analyzing the toxocariosis and its relationship with joint inflammatory disease in humans; since besides, exist two types of arthritis whose severity has been associated with the presence of Toxocara canis: rheumatoid arthritis and ankylosing spondylitis, which could be attributed to that this parasite induces constant secretion of a cytokine called interleukin-33, which has proinflammatory effects by activating mast cells, inducing a process of injury synovial membrane impacting joint progressively. It would be interesting to include toxocariosis, among the possible causes that generate or increase the severity of arthritis, in order to lead implementation of an appropriate treatment in these patients to allow their successful recovery.
Downloads
References
[2] Chia-Kwung F, Chien-Wei L, Yu-Chieh Ch. Factors affecting disease manifestation of toxocarosis in humans: Genetics and environment. Vet Parasitol 2013; 193:342-352.
[3] Llanos M, Condori M, Ibañes T, Loza M. Parasitosis entérica en caninos (Canis familiaris) en el área urbana de Coroico, Nor Yungas Departamento de La Paz, Bolivia. J Selva Andina. Res Soc 2010; 1(1):37-49.
[4] Cazorla D, Morales P. Parásitos intestinales de importancia zoonótica en caninos domiciliarios de una población rural del estado Falcón, Venezuela. Bol Malariol San Amb Enero-Julio 2013; LIII (1):19-28.
[5] Huerto E, Fonseca A, Dámaso B. Prevalencia de enteroparásitos zoonóticos en perros (Canis familiaris) y el nivel de cultura ambiental orientado a mascotas en Huánuco. Ágora Rev Cient 2015; 2(2):233-239.
[6] García L, López M, Laffont H, Bojanich M, Martín U. Seroprevalencia de Toxocara canis en perros de las ciudades de Corrientes y Esperanza (Argentina). Rev vet 2014; 25(2):131-134.
[7] Suárez O, Atencio A, Carruyo M, Fernández P, Villalobos R, Rivero Z et al. Parasitosis intestinales y tisulares y su relación con la eosinofilia en una comunidad indígena Yukpa de la Sierra de Perijá. Estado Zulia. Kasmera 2013; 41(1):27-41.
[8] Gallardo J, Camacho S. Infección por Toxocara canis y factores de riesgo en niños de la comunidad Agua Azul, estado Yaracuy. Salud Arte Cuidad 2012; 5(1):21-27.
[9] Espinoza Y, Vildózola H, Jiménez S, Roldán W, Huapaya P, Villar C et al. Prevalencia estimada de toxocariosis humana en la Región Lima. An Facmed 2016; 77(1):21-24.
[10] Henríquez A. Seroprevalencia de toxocariasis en habitantes de San Juan, municipio Sucre, estado Sucre. Tesis de grado. Universidad de Oriente Núcleo de Sucre, Escuela de Ciencias Departamento de Bioanálisis. 2013. Disponible en: URL:http://ri.bib.udo.edu.ve/bitstream/123456789/3588/1/TESIS_AH.pdf 4/7/16
[11] Garcia G, De Lima P, Mendonca M, Nunes A, McBride A, Scaini C et al. Human toxocariasis: current advances in diagnostics, treatment and interventions. Trends Parasitol 2014; 30(9):456-464.
[12] Macpherson C. The epidemiology and public health importance of toxocariasis: A zoonosis of global importance. Int J Parasitol 2013; 43:999-1008.
[13] Silva M, Amor A, Santos L, Galvão A, Oviedo A, Silva E et al. Risk factors for Toxocara spp. seroprevalence and its association with atopy and asthma phenotypes in school-age children in a small town and semi-rural areas of Northeast Brazil. ACTROP 2016; 3916:1-7.
[14] Kanobana K, Vereecken K, Junco R, Sariego I, Rojas L, Bonet M et al. Toxocara seropositivity, atopy and asthma: a study in Cuban schoolchildren. Trop Med Int Health 2013; 18(4):403-406.
[15] Lingling L, Wei G, Xiao Y, Dandan W, Hui B, Sini Z et al. Asthma and toxocariasis. Ann Allergy, Asthma Immunol 2014; 113(2):187-192.
[16] Bellanger A, Bamoulid J, Millon L, Chalopin J, Humbert P. Rheumatoid purpura associated with toxocariasis. Can Fam Physician 2011; 57:1413-1414.
[17] Viola G, Giacomin M, Franca C, Sallum A, Jacob C, Silva C. Poliartrite crônica como manifestacão isolada da toxocaríase. Rev Bras Reumatol 2014; 133:1-3.
[18] Jiménez F, García J, Ríos R, Zonana A, Tapia R, Villanueva N. Isolation of IgG antibodies to Toxocara in ankylosing spondylitis patients with acute anterior uveitis. Korean J Ophthalmol 2014; 28(3):207-212.
[19] Rayes A, Lambertucci J. Human toxocariasis as a posible cause of eosinophilic arthritis. Rheumatol 2001; 40:109-110.
[20] Jimenez F, Camargo A, Gargia J, Zonana A, Alcantara I, Carrillo L et al. A study on parasites in Mexican rheumatic disease patients. J Egypt Soc Parasitol 2012; 42(2):271-280.
[21] Jiménez F, Méndez P, Tapia R, De la Rosa J. Relationship between antibodies to Toxocara and the disability of the human ankylosing spondylitis. Am J Infect Dis 2015; 11(1):1-6.
[22] Resende N, Gazzinelli P, Barbosa F, Oliveira L, Nogueira D, Gazzinelli A et al. New insights into the immunopathology of early Toxocara canis infection in mice. Parasit Vectors 2015; 8:1-11.
[23] Palmer G y Gabay C. Interleukin-33 biology with potential insights into human diseases. Nat Rev Rheumatol 2011; 7:321-329.
[24] National Institute of Arthritis and Musculoskeletal and Skin Diseases. Arthritis and Rheumatic Diseases. Octubre, 2014. Disponible en: URL: http://www.niams.nih.gov/Health_Info/Arthritis/arthritis_rheumatic.pdf5/7/16
[25] Cazorla D, Morales P, Acosta M. Contaminación de suelos con huevos de Toxocara spp. (Nematoda, Ascaridida) en parques públicos de la ciudad de Coro, estado Falcón, Venezuela. Rev Cient, FCV-LUZ 2007; 17(2):117-122.
[26] Acha P, Szyfres B. Larva migrans visceral y toxocariasis. En: Organización Panamericana de la Salud, editores. Zoonosis y enfermedades transmisibles comunes al hombre y a los animales. 3 ed. Vol. 3. Washington, D.C; 2003. p. 305-311.
[27] Gallardo J, Forlano M. Diagnóstico de huevos de Toxocara spp. del suelo en parques y plazas públicas de la ciudad de Barquisimeto, estado Lara, Venezuela. Gaceta Cs Vet 2015; 20(1):4-9.
[28] Strube C, Heuer L, Janecek E. Toxocara spp infections in paratenic hosts. Vet Parasitol 2013; 193:375-389.
[29] Aranzamendi C, Sofronic L, Pinelli E. Helminths: Immunoregulation and inflammatory diseases. Which side Are Trichinella spp and Toxocara spp. on?. J Parasitol Res 2013; Article ID 329438:1-11.
[30] Ribeiro L, Valente R, Cavalcante V, Figueiredo C, Fiaccone R, Santos J et al. Toxocara seropositivity, atopy and wheezing in children living in poor neighbourhoods in urban latinamerican. PloS Negl Trop Dis 2012; 6(11):1-9.
[31] Serrano H. Células colaboradoras (TH1, TH2, TH17) y reguladoras (Treg, TH3, NKT) en la artritis reumatoide. Reumatol Clin 2009; 5(S1):1–5.
[32] Bicalho R, Macedoa V, Kakehasib A, Melo M. IL33 in rheumatoid arthritis: potential contribution to pathogenesis. Rev Bras Rumatol 2016; 288:1-7.
[33] Enoksson M, Lyberg K, Moller C, Fallon P, Nilsson G, Lunderius C. Mast cells as sensors of cell injury through IL-33 recognition. J Immunol 2011; 186:2523-2528.
[34] Sumei Tang, Heqing Huang, Fanlei Hu, Wei Zhou, Jianping Guo, Huirong Jiang et al. Increased IL-33 in synovial fluid and paired serum is associated with disease activity and autoantibodies in rheumatoid arthritis. Clin Dev Immunol 2013; Article ID 985301:1-6.
[35] Lihua D, JieCh, Feili G, Guixiu Sh. The role of IL-33 in rheumatic diseases. Clin Dev Immunol 2013; Article ID 924363:1-5.
[36] Talabot D, McKeec T, Gindrec P, Basa S, Baetend D, Gabaya C et al. Distinct serum and synovial fluid interleukin (IL)-33 levels in rheumatoid arthritis, psoriatic arthritis and osteoarthritis. Joint Bone Spine 2012; 79(1):32-37.
[37] Kaplan M, Kamanli A, Kalkan A, Kuk S, Gülkesen A, Ardiçoğlu O et al. Toxocariasis seroprevalence in patients with rheumatoid arthritis. Turkiye Parazitol Derg 2005; 29(4):251-254.
[38] Lunderius C, Enoksson M, Nilsson G. Mast cells respond to cell injury through the recognition of IL-33. Front Immunol 2012; 3(82):1-9.
[39] Pei Ch, Barbour M, Fairlie K, Allan D, Mu R, Jiang H. Emerging role of interleukin-33 in autoimmune diseases. Immunol 2013; 141:9-17.
[40] Verri W, Souto F, Vieira S, Almeida S, Fukada S, Xu D et al. IL-33 induces neutrophil migration in rheumatoid arthritis and is a target of anti-TNF therapy. Ann Rheum Dis 2010; 69:1697-1703.
[41] Abdel-Wahab S, Tharwat I, Atta D, El-Sammak A, Atef R. Serum level of interleukin-33 in rheumatoid arthritis patients and its association with bone erosion and interstitial lung disease. The Egyptian Rheumatol 2016; 38:99-104.
[42] Xu D, Jiang H, Kewin P, Li Y, Mu R, Fraser A et al. IL-33 exacerbates antigen-induced arthritis by activating mast cells. PNAS 2008; 105(31):10913-10918.
Published
How to Cite
Issue
Section
Gaceta de Ciencias Veterinarias se apega al modelo Open Access, por ello no se exige suscripción, registro o tarifa de acceso a los usuarios o instituciones. Los usuarios pueden leer, descargar, copiar, distribuir, imprimir y compartir los textos completos inmediatamente después de publicados, se exige no hacer uso comercial de las publicaciones. Para la reproducción parcial o total de los trabajos o contenidos publicados, se exige reconocer los derechos intelectuales de los autores y además, hacer referencia a esta revista. La publicación de artículos se hace sin cargo para los autores. Los trabajos pueden consultarse y descargarse libremente, y de manera gratuita, en extenso en versión digital, desde su enlace Web institucional. Los textos publicados son propiedad intelectual de sus autores. Las ideas, opiniones y conceptos expuestos en los trabajos publicados en la revista representan la opinión de sus autores, por lo tanto, son estos los responsables exclusivos de los mismos.
