Niveles séricos de il-8, il-10, il-13, ifnγ y tnfα en pacientes pediátricos con infección aguda por diferentes serotipos de virus dengue

Joanna Santeliz Casavilca; William Lopez; Elis Mosquera; Antonio Guerrero; Isabel Alvarez

Authors

Joanna Santeliz Casavilca University Centrocidental Lisandro Alavarado, Venezuela.
William Lopez University Centrocidental Lisandro Alavarado, Venezuela.
Elis Mosquera University Centrocidental Lisandro Alavarado, Venezuela.
Antonio Guerrero University Centrocidental Lisandro Alavarado, Venezuela.
Isabel Alvarez University Centrocidental Lisandro Alavarado, Venezuela.

Keywords:

Dengue, Elisa, Interleukins, PCR-TR, TH1/TH2

Abstract

Dengue is an acute febrile disease caused by four dengue virus (DENV) serotypes whose prevalence in the Americas has quintupled between 2003 and 2013. The immune response against the infection with dengue virus involves cellular and humoral factors. We performed an observational and cross-sectional study to evaluate the levels of interleukins of the innate immune response (IL-8, TNFα), TH1 response (IFNγ), TH2 (IL-13) and regulatory (IL-10) in serum of patients during the acute phase of infection with the DENV1, DENV3 and DENV4 serotypes.

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Author Biographies

Joanna Santeliz Casavilca, University Centrocidental Lisandro Alavarado, Venezuela.

Doctor.Specialist in Pneumonology. Teacher Titular Decanato Cs. Of the health.
University Centroccidental Lisandro Alvarado

William Lopez, University Centrocidental Lisandro Alavarado, Venezuela.

Agroindustrial Technician. Physiology section. Deanship Cs de la Salud University
Centroccidental Lisandro Alvarado.

Elis Mosquera, University Centrocidental Lisandro Alavarado, Venezuela.

Agroindustrial Technician. Physiology section. Deanship Cs de la Salud University
Centroccidental Lisandro Alvarado

Antonio Guerrero, University Centrocidental Lisandro Alavarado, Venezuela.

Technical Microbiology Section of Microbiology Dec Cs of Health Universidad Centroccidental
Lisandro Alvarado

Isabel Alvarez, University Centrocidental Lisandro Alavarado, Venezuela.

Lic. Bionalisis. Specialty in Bacterilogy. Associate Professor Microbilogia section.
Dept. of preventive and social medicine Decanato cs de la Salud. Centroccidental University
Lisandro Alvarado.

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Serum levels of il-8, il-10, il-13, ifnγ and tnfα in pediatric patients with acute infection with different dengue virus serotypes