Association between biomarkers for transfusion-transmitted infections and blood groups in donors from El Tocuyo, Lara, Venezuela
Keywords:
blood group antigens, biomarkers, transfusion-transmitted infections.Abstract
Various studies in recent years links the ABO and Rh blood systems with different diseases such as ovarian or breast cancer, peptic ulcer, and even multiple sclerosis; however, when associated with transfusion-transmitted infections (TTI), controversy persists between their possible biological relationship. The early recognition of some biological or immunological phenotype prone to some TTIs, could be useful to help quickly identify patients at risk of suffering them. For this reason, the present research was aimed at determining the distribution of TTI and their specific association with ABO and Rh blood groups in blood donors who attended the Dr. Egidio Montesinos Hospital in the city El Tocuyo from Lara state, during the period 2010 to 2019. For this, 8362 blood samples were analyzed by the hemagglutination tube technique with monospecific sera to determine the ABO and Rh groups, as well as the seven TTI mandatory biomarkers performed in a venezuelan blood bank through the ELISA test of different biotech companies. It was found that the type O blood group was the most numerous as was the phenotype positive for the Rh blood system, a prevalence of 7 % was observed for any biological marker, with the indicator of hepatitis B being the most observed. The results show that TTI are commonly evidenced in the Rh-positive blood and with the blood group O. When researching the association between these uninominal variables with the Chi square test, it was found that there is a statistically significant association between the anti-HBc biomarker with both group O and the Rh-positive group, so it is concluded that the donors of the above-mentioned groups are likely to express hepatitis B.
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References
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(21). Diasorin (2009). ICE* Syphilis. Inmunoensayo enzimático para la detección de anticuerpos contra Treponema pallidum. [Acceso 23.01.2019]; Disponible en: http://www.annardx.com/productos/images/productos/banco-de-sangre/infecciosas/Murex-Ice-Syphilis.pdf.
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(23). Ruiz-Mendoza L, Villegas-Gracia R, Cardona-Arias J. Prevalencia de agentes transmisibles por transfusión y factores asociados en un banco de sangre de Córdoba-Colombia 2014-2016. Revista U.D.C.A Actualidad & Divulgación Científica 2018;21(2):297-308.
(24). Ley de Transfusión y Bancos de sangre. Gaceta Oficial de la República de Venezuela. Caracas, martes 8 de noviembre de 1977. Número 31356.
(25). Normas para la investigación en muestras biológicas. En: Código de ética para la vida, Caracas: Ministerio del Poder Popular para la Ciencia, Tecnología e Industrias Intermedias; 2011, p. 71-76.
(26). Cardona-Arias JA, Flórez-Duque J, Higuita-Gutiérrez LF. Seroprevalencia del virus de la hepatitis C en un banco de sangre de Medellín-Colombia, 2005-2018. Acta biol. Colomb. 2019;24(3):486-492.
(27). O´Neil D. Distribution of blood types [Internet]. Modern human variation: An Introduction to contemporary human biological diversity. [Acceso 23.01.2019]; Disponible en: https://www2.palomar.edu/anthro/vary/vary_3.htm
(28). Deepthi KG, Sreedhar Babu KV, Arun R, Jothibai DS. Prevalence of principal Rh blood group antigens in blood donors at the blood bank of a tertiary care hospital in southern India. Journal of Clinical and Diagnostic Research 2016;10(5):7-10.
(29). Mavenyengwa R, Mukesi M, Chipare I, Shoombe E. Prevalence of human immunodeficiency virus, syphilis, hepatitis B and C in blood donations in Namibia. BMC Public Health 2014;14:424.
(30). Patel J, Dighe M, Kothari F, Rajvanshi R. Transfusion transmitted infections and its association with ABO and Rh blood group system among blood donors in Vadodara, Gujarat. International Journal of Scientific Research 2019;8(6):55-57.
(31). Siraj N, Okoth Achila O, Issac J, Menghisteab E, Hailemariam M, Hagos S et al. Seroprevalence of transfusion-transmissible infections among blood donors at National Blood Transfusion Service, Eritrea: a seven-year retrospective study. BMC Infect Dis. [Internet] 2018;18:264. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992706/
(32). Pérez D, Mattar S. Prevalencia de marcadores infecciosos en el banco de sangre del Hospital San Jerónimo de Montería: 1996-2001. Infectio. [Internet] 2003. [Acceso 23.01.2019]; 7(1):15-20. Disponible en: http://www.revistainfectio.org/index.php/infectio/article/view/276
(33). Herrera-Martinez AD, Rodriguez-Morales AJ. Trends in the seroprevalence of antibodies against Trypanosoma cruzi among blood donors in a western hospital of Venezuela, 2004-2008. Acta Trop. 2010;116:115-117.
(34). Gómez LA, Peñuela O, Higuera F. Prevalence of antibodies against transfusion-transmissible infections (TTI) in blood donors from the Colombian eastern region. Clin Lab. 2014;60(5):869-871.
(35). Giraldo-Valencia EC, Morales-Gallo ME, Maya-Guerrero MA, Rendón-Castrillón LE, Cardona Arias JA. Prevalencia de marcadores de infecciones transmisibles y su relación con variables demográficas en un banco de sangre de Antioquia-Colombia, 2010-2013. Rev CES Med 2015;29(1):59-74.
(36). Das S, Kumar MLH. Association of blood group types to hepatitis B and hepatitis C virus infection among blood donors: a five years institutional based study. Int J Basic Appl Med Sci 2012;2:191-5.
(37). Singh Nigam J, Singh S, Kaur V, Giri S, Prakash Kaushal R. The prevalence of transfusion transmitted infections in ABO blood groups and Rh type system. Hematology Reports [Internet] 2014;6:5602. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274480/
(38). Batool Z, Haroon S, Tariq S. Association of ABO and Rh blood group types to hepatitis B, hepatitis C, HIV and syphilis infection, a five year’ experience in healthy blood donors in a tertiary care hospital. J Ayub Med Coll Abbottabad 2017;29(1):90-92.
(39). Dirisu JO, Alli TO, Adegoke AO, Osazuwa F. A Survey of prevalence of serum antibodies to human immunodeficiency deficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV) among blood donors. N Am J Med Sci,2011;3(1):35-38.
(40). Abate M, Wolde T. Seroprevalence of human immunodeficiency virus, hepatitis B Virus, hepatitis C Virus, and syphilis among blood donors at Jigjiga blood bank, Eastern Ethiopia. Ethiop J Health Sci. 2016 Mar;26(2):153-60.
(41). Ngassaki-Yoka CD, Ntsame-Ndong JM, Bisseye C. ABO, Rhesus blood groups and transfusion-transmitted infections among blood donors in Gabon. Sudan Journal of Medical Sciences 2018;13(1):12–21.
(42). Flórez-Duque J, Cardona-Arias JA, Infecciones en donantes de un banco de sangre de Medellín-Colombia, 2015-2016. Rev. investig. andin, 2018;37(20);161-176.
(2). Franchini M, Liumbruno G, Lippi G. The prognostic value of ABO blood group in cancer patients. Blood Transfus 2016;14(5):434-440.
(3). Suna W, Wenc Ch, Lina J, Wene C, Pua X, Huanga M. et al. ABO blood types and cancer risk-A cohort study of 339,432 subjects in Taiwan. Cancer Epidemiol. 2015;39(2):150-156.
(4). Iavarone M, Della Corte C, Pelucchi C, Marconi M, Trotti R, Triolo M. et al. Risk of hepatocellular carcinoma in relation to ABO blood type, Digestive and Liver Disease, 2015;48(1):94-96.
(5). Shiferaw E, Tadilo W, Melkie I, Shiferaw M. Sero-prevalence and trends of transfusion-transmissible infections among blood donors at Bahir Dar district blood bank, northwest Ethiopia: a four year retrospective study. PloS ONE 2019:14(4):16-18.
(6). Sharma P, Chaurasia RK, Singh P. Distribution of transfusion transmitted infections in ABO and Rh blood groups: a 5 year study. Ann. Int. Med. Den. Res. 2017;3(5):16-18.
(7). Akpu P, Victor O. Seroprevalence of hepatitis B and C viruses among eligible blood donors in a tertiary healthcare facility in Nasarawa state, Nigeria. JAMB 2017;4(2):1-6.
(8). Jana D, Jana N, Patel AK, Yadav N. ABO & Rh blood groups’ distribution among blood donors from southern Nepal and its relation with hepatitis B viral infection, International Journal of Health Sciences & Research 2018;8(5):45-50.
(9). Apecu R, Mulogo E, Bagenda F, Byamungu A, Boum Y, Bazira J. et al. Seroprevalence of human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV) and syphilis among voluntary blood donors in rural southwestern Uganda: a retrospective study. IJTDH 2017;24(3):1-13.
(10). Neil SJ, McKnight A, Gustafsson K, Weiss RA. HIV-1 incorporates ABO histo-blood group antigens that sensitise virions to complement-mediated inactivation. Blood 2004;11:42-67.
(11). Onsten TGH, Callegari-Jacques SM, Goldani LZ. The higher frequency of blood group B in a brazilian population with HIV infection, The Open AIDS Journal 2013;7:47-50.
(12). Mohammadali F, Pourfathollah A. Association of ABO and Rh blood groups to blood borne infections among blood donors in Tehran–Iran. Iranian J Publ Health 2014;43(7):981-989.
(13). Naseri Z, Ghannad MS, Hosseini SM, Roshanaei G, Nejad ASM, Mohammadi A. Evaluation of accompaniment of ABO blood groups system and Rhesus blood group types with infection to hepatitis B virus and hepatitis C virus in Hamadan, Iran. Int J Med Res Health Sci. 2016;5(4):1-5).
(14). Behzad-Behbahani A, Mafi-Nejad A, Tabei SZ, Lankarani KB, Torab A, Moaddeb A. Anti-HBc & HBV-DNA detection in blood donors negative for hepatitis B virus surface antigen in reducing risk of transfusion associated HBV infection. Indian J Med Res. 2006;123(1):37-42.
(15). Arveláez-García CA. Sistema de grupo sanguíneo ABO. Medicina & laboratorio [Internet]. 2009 [Acceso 23.01.2019]; 15:329-347. Disponible en: https://www.medigraphic.com/pdfs/medlab/myl-2009/myl097-8c.pdf
(16). Instituto de Salud Pública. Ministerio de salud. Gobierno de Chile. Virus hepatitis B (Antígeno de superfície HBsAg). [Acceso 23.01.2019]; Disponible en: http://www.ispch.cl/virus-hepatitis-b-antigeno-de-superficie-hbsag
(17). Diasorin (2014). Murex anti-HBc (total). Enzimoinmunoanálisis para la detección de anticuerpos frente al antígeno core del virus de la hepatitis B (anti-HBc) en suero o plasma humanos. [Acceso 23.01.2019]; Disponible en:
http://www.annardx.com/productos/images/productos/diagnostica/infecciosas/Murex-Anti-HBc-Total.pdf
(18). World Health Organization. (2015). Prequalification of in vitro diagnostics programme. Public Report. Murex anti-HCV (version 4.0). [Acceso 23.01.2019]; Disponible en: http://www.annardx.com/productos/images/productos/diagnostica/infecciosas/Murex-Anti-HCV-version-4.0.pdf
(19). Abbott Diagnostics Division (2009). Murex HIV Ag/Ab Combination. Enzyme immunoassay for improved detection of seroconversion to human immunodeficiency virus types 1 (HIV-1, HIV-1 group O) and detection of anti-HIV-2 antibodies. [Acceso 23.01.2019]; Disponible en: http://www.annardx.com/productos/images/productos/diagnostica/infecciosas/hiv-combopdf.pdf
(20). Diasorin (2009). Murex HTLV I+II. Enzimoinmunoanálisis cualitativo para la detección de anticuerpos frente al virus T-linfotrópico humano de tipo I y II. [Acceso 23.01.2019]; Disponible en: http://www.annardx.com/productos/images/productos/diagnostica/infecciosas/murex-htlv-iiipdf.pdf.
(21). Diasorin (2009). ICE* Syphilis. Inmunoensayo enzimático para la detección de anticuerpos contra Treponema pallidum. [Acceso 23.01.2019]; Disponible en: http://www.annardx.com/productos/images/productos/banco-de-sangre/infecciosas/Murex-Ice-Syphilis.pdf.
(22). GrupoBios. (2018). Test Elisa para Chagas III. Ensayo inmunoenzimático in vitro para la detección cualitativa de anticuerpos de la clase IgG dirigidos contra el Trypanosoma cruzi en muestras de suero o plasma humano. [Acceso 23.01.2019]; Disponible en: https://chagas.cl/wp-content/uploads/2018/01/descrip-espanol.pdf.
(23). Ruiz-Mendoza L, Villegas-Gracia R, Cardona-Arias J. Prevalencia de agentes transmisibles por transfusión y factores asociados en un banco de sangre de Córdoba-Colombia 2014-2016. Revista U.D.C.A Actualidad & Divulgación Científica 2018;21(2):297-308.
(24). Ley de Transfusión y Bancos de sangre. Gaceta Oficial de la República de Venezuela. Caracas, martes 8 de noviembre de 1977. Número 31356.
(25). Normas para la investigación en muestras biológicas. En: Código de ética para la vida, Caracas: Ministerio del Poder Popular para la Ciencia, Tecnología e Industrias Intermedias; 2011, p. 71-76.
(26). Cardona-Arias JA, Flórez-Duque J, Higuita-Gutiérrez LF. Seroprevalencia del virus de la hepatitis C en un banco de sangre de Medellín-Colombia, 2005-2018. Acta biol. Colomb. 2019;24(3):486-492.
(27). O´Neil D. Distribution of blood types [Internet]. Modern human variation: An Introduction to contemporary human biological diversity. [Acceso 23.01.2019]; Disponible en: https://www2.palomar.edu/anthro/vary/vary_3.htm
(28). Deepthi KG, Sreedhar Babu KV, Arun R, Jothibai DS. Prevalence of principal Rh blood group antigens in blood donors at the blood bank of a tertiary care hospital in southern India. Journal of Clinical and Diagnostic Research 2016;10(5):7-10.
(29). Mavenyengwa R, Mukesi M, Chipare I, Shoombe E. Prevalence of human immunodeficiency virus, syphilis, hepatitis B and C in blood donations in Namibia. BMC Public Health 2014;14:424.
(30). Patel J, Dighe M, Kothari F, Rajvanshi R. Transfusion transmitted infections and its association with ABO and Rh blood group system among blood donors in Vadodara, Gujarat. International Journal of Scientific Research 2019;8(6):55-57.
(31). Siraj N, Okoth Achila O, Issac J, Menghisteab E, Hailemariam M, Hagos S et al. Seroprevalence of transfusion-transmissible infections among blood donors at National Blood Transfusion Service, Eritrea: a seven-year retrospective study. BMC Infect Dis. [Internet] 2018;18:264. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992706/
(32). Pérez D, Mattar S. Prevalencia de marcadores infecciosos en el banco de sangre del Hospital San Jerónimo de Montería: 1996-2001. Infectio. [Internet] 2003. [Acceso 23.01.2019]; 7(1):15-20. Disponible en: http://www.revistainfectio.org/index.php/infectio/article/view/276
(33). Herrera-Martinez AD, Rodriguez-Morales AJ. Trends in the seroprevalence of antibodies against Trypanosoma cruzi among blood donors in a western hospital of Venezuela, 2004-2008. Acta Trop. 2010;116:115-117.
(34). Gómez LA, Peñuela O, Higuera F. Prevalence of antibodies against transfusion-transmissible infections (TTI) in blood donors from the Colombian eastern region. Clin Lab. 2014;60(5):869-871.
(35). Giraldo-Valencia EC, Morales-Gallo ME, Maya-Guerrero MA, Rendón-Castrillón LE, Cardona Arias JA. Prevalencia de marcadores de infecciones transmisibles y su relación con variables demográficas en un banco de sangre de Antioquia-Colombia, 2010-2013. Rev CES Med 2015;29(1):59-74.
(36). Das S, Kumar MLH. Association of blood group types to hepatitis B and hepatitis C virus infection among blood donors: a five years institutional based study. Int J Basic Appl Med Sci 2012;2:191-5.
(37). Singh Nigam J, Singh S, Kaur V, Giri S, Prakash Kaushal R. The prevalence of transfusion transmitted infections in ABO blood groups and Rh type system. Hematology Reports [Internet] 2014;6:5602. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274480/
(38). Batool Z, Haroon S, Tariq S. Association of ABO and Rh blood group types to hepatitis B, hepatitis C, HIV and syphilis infection, a five year’ experience in healthy blood donors in a tertiary care hospital. J Ayub Med Coll Abbottabad 2017;29(1):90-92.
(39). Dirisu JO, Alli TO, Adegoke AO, Osazuwa F. A Survey of prevalence of serum antibodies to human immunodeficiency deficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV) among blood donors. N Am J Med Sci,2011;3(1):35-38.
(40). Abate M, Wolde T. Seroprevalence of human immunodeficiency virus, hepatitis B Virus, hepatitis C Virus, and syphilis among blood donors at Jigjiga blood bank, Eastern Ethiopia. Ethiop J Health Sci. 2016 Mar;26(2):153-60.
(41). Ngassaki-Yoka CD, Ntsame-Ndong JM, Bisseye C. ABO, Rhesus blood groups and transfusion-transmitted infections among blood donors in Gabon. Sudan Journal of Medical Sciences 2018;13(1):12–21.
(42). Flórez-Duque J, Cardona-Arias JA, Infecciones en donantes de un banco de sangre de Medellín-Colombia, 2015-2016. Rev. investig. andin, 2018;37(20);161-176.
Published
2020-09-16
How to Cite
Vizcaya-Rodríguez, T., & Torres, L. (2020). Association between biomarkers for transfusion-transmitted infections and blood groups in donors from El Tocuyo, Lara, Venezuela. Revista Venezolana De Salud Pública, 8(2), 22-47. Retrieved from https://revistas.uclave.org/index.php/rvsp/article/view/2972
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