Medicinal use of Solanun nigrum and its relationship to the presence of secondary metabolites

Authors

  • Valdano Tafur Universidad Central del Ecuador. Facultad de Ciencias Agrícolas. Quito, Ecuador
  • Edgar G. Tello Universidad Central del Ecuador. Facultad de Ciencias Agrícolas. Quito, Ecuador
  • Duilio Torres Rodríguez Universidad Centroccidental Lisandro Alvarado. Decanato de Agronomía. Lara. Venezuela.
  • Yelitza García Orellana Universidad Centroccidental Lisandro Alvarado. Decanato de Agronomía. Lara. Venezuela.
  • Juan Brito Borges Centro de Investigaciones Agrícolas del Estado Lara, Instituto Nacional de Investigaciones Agrícola. Venezuela.

Keywords:

Extracts, medicinal plants, solanaceous

Abstract

Solanum nigrum is a solanaceous plant widely distributed in tropical regions, traditionally used for the treatment of various pathologies. The objective of this research was to carry out a search in bibliographical bases of scientific information, to establish the relation of the pharmacological properties attributed to the plant with the presence of secondary metabolites. The results reveal that S. nigrum is of massive use with pharmacological purposes, being the extracts prepared with the leaves and fruits of the plant the most used for antipyretic and dermatological analgesic purposes. The systematic review of literature in the database attributes the pharmacological potential of the plant to the concentration of secondary metabolites in the reproductive and vegetative organs of the plant

Downloads

Download data is not yet available.

References

Abbas, K., Niaz, U., Hussain, T., Saeed, M. A., Javaid, Z., Idrees, A., & Rasool, S. (2014). Antimicrobial activity of fruits of Solanum nigrum and Solanum xanthocarpum. Acta Pol Pharm, 71(3), 415-21. Disponible: https://www.ptfarm.pl/pub/File/Acta_Poloniae/2014/3/acta3-2014.pdf#page=67 [Consulta: 2020, Enero 14].

Abdel O, Youness E Hafez H. 2011. The antioxidant status of the plasma in patients with breast cancer undergoing chemotherapy. Open Journal of Molecular and Integrative Physiology, 1: 29-35.

Abdel-Wahhab, M. A., Ahmed, H. M., Abdel-Aziem, S. H., El-Nekeety, A. A., Abd El-Kader, H. A., Abdel-Aziz, M. S., . & El-Denshary, E. S. (2017). Modulation of hepatotoxicity, DNA fragmentation and gene expression of Solanum nigrum leaves extract in rats treated with silver nanoparticles. Journal of Applied Pharmaceutical Science, 7(02). Disponible: https://www.japsonline.com/admin/php/uploads/2148_pdf.pdf [Consulta: 2019, Diciembre 8].

Albouchi, F., Attia, M., Hanana, M., & Hamrouni, L. (2018). Ethnobotanical Notes and Phytopharmacologiques on Solanum nigrum Linn.(Family: Solanaceae). American Journal of Phytomedicine and Clinical Therapeutics, 6(1): 5.

Atanu, F. O., Ebiloma, U. G., & Ajayi, E. I. (2011). A review of the pharmacological aspects of Solanum nigrum Linn. Biotechnol Mol Biol Rev, 6(1), 1-7.

Ayyanar, P., Murugan, R., & Manoharan, N. (2017). Protective role of solanum nigrum linn leaf methanol extract on male wistar albino rats against n-nitrosodiethyl amine induced hepatocarcinoma. European Journal of Biomedical, 4(12), 365-373.

Baharvand-Ahmadi, B., Bahmani, M., Eftekhari, Z., Jelodari, M., & Mirhoseini, M. 2015. Overview of medicinal plants used for cardiovascular system disorders and diseases in ethnobotany of different areas in Iran. Journal of HerbMed Pharmacology, 5(1), 39-44.

Bermúdez, A., & Velázquez, D. (2002). Etnobotánica médica de una comunidad campesina del estado Trujillo, Venezuela: un estudio preliminar usando técnicas cuantitativas. Rev Fac Farm, 44, 2-6.

Bhavani, R., Geetha, G., Santhoshkumar, J., & Rajeshkumar, S. (2015). Evaluation of Antibacterial action and Hepatoprotective efficiency of Solanum nigrum leaves extract on acetaminophen induced hepatotoxicity. Research Journal of Pharmacy and Technology, 8(7), 893-900. Disponible:https://doi.org/10.5958/0974-360X.2015.00145.6 [Consulta: 2020, Enero 28].

Campisi, A., Acquaviva, R., Raciti, G., Duro, A., Rizzo, M., & Santagati, N. A. (2019). Antioxidant Activities of Solanum nigrum L. Leaf Extracts Determined in In Vitro Cellular Models. Foods, 8(2), 63. https://doi.org/10.3390/foods8020063

Carmona, J., Gil, R., & Rodríguez, M. C. (2008). Descripción taxonómica, morfológica y etnobotánica de 26 hierbas comunes que crecen en la ciudad de Mérida-Venezuela. Boletín Antropológico, 26(73), 113-129.

Chase, T. R., Cham, K. E., & Cham, B. E. 2019. Solasodine Glycosides from the Eggplant in a Topical Cream Psorend BEC Are Effective against Psoriasis. International Journal of Clinical Medicine, 10(03), 174. Disponible: . https://doi.org/10.4236/ijcm.2019.103017 [Consulta: 2020, Enero 30].

Chester, K., Zahiruddin, S., Ahmad, A., Khan, W., Paliwal, S., & Ahmad, S. (2019). Bioautography-based identification of antioxidant metabolites of Solanum nigrum L. and exploration its hepatoprotective potential against D-galactosamine-induced hepatic fibrosis in rats. Pharmacognosy Magazine, 15(62). Disponible: http://www.phcog.com/article.asp?issn=0973-1296;year=2019;volume=15;issue=62;spage=104;epage=110;aulast=Chester [Consulta: 2020, Enero 15].

Dar KB, Bhat AH, Amin S, Zargar MA, Masood A, et al. 2017. Evaluation of Antibacterial, Antifungal and Phytochemical Screening of Solanum nigrum. Biochem Anal Biochem 6: 309.

Dasgupta, N., Muthukumar, S. P., & Murthy, P. S. (2016). Solanum nigrum leaf: natural food against diabetes and its bioactive compounds. Research Journal of Medicinal Plants, 10, 181-193.

El-Hawary, S. S., Mohammed, R., AbouZid, S. F., Bakeer, W., Ebel, R., Sayed, A. M., & Rateb, M. E. (2016). Solamargine production by a fungal endophyte of Solanum nigrum. Journal of applied Microbiology, 120(4), 900-911. Disponible: https://doi.org/10.1111/jam.13077 [Consulta: 2020, Febrero 10].

Fairlie-Jones, L., Davison, K., Fromentin, E., & Hill, A. M. (2017). The effect of anthocyanin-rich foods or extracts on vascular function in adults: A systematic review and meta-analysis of randomised controlled trials. Nutrients, 9(8), 908. Disponible:https://doi.org/10.3390/nu9080908 [Consulta: 2019, Diciembre 1].

Fernández, E., Espinel-Jara, V., Gordillo-Alarcón, S., Castillo-Andrade, R., Žiarovská, J., Zepeda-Del Valle, J. M., & Lara-Reimers E. A. (2019). Estudio etnobotánico de plantas medicinales utilizadas en tres cantones de la provincia Imbabura, Ecuador. Agrociencia, 53(5), 797-810.

Galvis Rueda, M., & Torres Torres, M. (2017). Etnobotánica y usos de las plantas de la comunidad rural de Sogamoso, Boyacá, Colombia. Revista de investigación agraria y ambiental, 8(2), 187-206. Disponible: https://dialnet.unirioja.es/servlet/articulo?codigo=6285368 [Consulta: 2019, Noviembre 17].

García-González, A. I., y Rosas-Carrasco, O. (2017). Herpes zoster (HZ) y neuralgia posherpética (NPH) en el adulto mayor: particularidades en la prevención, el diagnóstico y el tratamiento. Gaceta médica de México, 153(1), 92-101.

Giorgetti, M., & Negri, G. (2011). Plants from Solanaceae family with possible anxiolytic effect reported on 19th century's Brazilian medical journal. Revista Brasileira de Farmacognosia, 21(4), 772-780.

Godara, S. K., Kumar, N., Kumari, P., & Ram, S. (2019). Ethnomedicinal uses of some plants of moraceae and solanaceae family of hamirpur district in Himachal Pradesh. Life sciences leaflets, 114, pp.1-8.

Jagtap, C. Y., Prajapati, P. K., Rudrappa, H. C., & Shukla, V. J. (2013). Pharmacognostic and phytochemical investigation of root of Solanum nigrum Linn.: An ethnomedicinally important herb. International Journal of Green Pharmacy (IJGP), 7(1).

Jain, R., Sharma, A., Gupta, S., Sarethy, I. P., & Gabrani, R. (2011). Solanum nigrum: current perspectives on therapeutic properties. Altern Med Rev, 16(1), 78-85.

Javed, T., Ashfaq, U. A., Riaz, S., Rehman, S., & Riazuddin, S. (2011). In-vitro antiviral activity of Solanum nigrum against Hepatitis C Virus. Virology Journal, 8(1), 26. Disponible: https://doi.org/10.1186/1743-422X-8-26.[Consulta: 2020, Febrero 10].

Joseph, J., Joseph, L. & George, M. (2017). Antiepileptic and Antioxidant Activity of Some Medicinal Plants: A Review. International Journal of Pharmacognosy and Phytochemical Research, 9. Disponible: https://doi.org/10.25258/phyto.v9i10.10452 [Consulta: 2020, Febrero 20].

Kumar, P., Kumar, J., Kumar, R., & Dubey, R. C. (2016). Studies on phytochemical constituents and antimicrobial activities of leaves, fruits and stems of Solanum nigrum L. Asian Journal of Plant Science and Research, 6(4), 57-68.

Lai, Y. J., Tai, C. J., Wang, C. W., Choong, C. Y., Lee, B. H., Shi, Y. C., & Tai, C. J. (2016). Anti-cancer activity of Solanum nigrum (AESN) through suppression of mitochondrial function and epithelial-mesenchymal transition (EMT) in breast cancer cells. Molecules, 21(5), 553. Disponible: https://doi.org/10.3390/molecules21050553 [Consulta: 2020, Enero 14].

Ling, B., Xiao, S., Yang, J., Wei, Y., Sakharkar, M. K., & Yang, J. (2019). Probing the Antitumor Mechanism of Solanum nigrum L. Aqueous Extract against Human Breast Cancer MCF7 Cells. Bioengineering, 6(4), 112. Disponible:https://doi.org/10.3390/bioengineering6040112 [Consulta: 2020, Enero 15].

Liu, F. P., Ma, X., Li, M. M., Li, Z., Han, Q., Li, R., ... & Lin, Y. X. (2016). Hepatoprotective effects of Solanum nigrum against ethanol-induced injury in primary hepatocytes and mice with analysis of glutathione S-transferase A1. Journal of the Chinese Medical Association, 79(2), 65-71. Disponible: http://dx.doi.org/10.1016/j.jcma.2015.08.013 [Consulta: 2020, Febrero 10].

Mateo-Rivera, I. A., & Jiménez-Corona, A. E. (2019). Plantas medicinales usadas en la terapéutica de pacientes con hipertensión y diabetes mellitus tipo II, de la región indígena Tepehuana. Ciencia Huasteca Boletín Científico De La Escuela Superior De Huejutla, 7(13), 30-36.

Mazher, M., Anjum, M., Mushtaq, W., Noshad, Q., & Malik, N. Z. (2017). Antifungal assay of Solanum nigrum Linn. fruit, leaves and stems extracts in different solvents. Int J Biosci, 10(4), 380-385.

Mbah, U. O., Egbuonu, A. C. C., Omodamiro, O. D., Jeremiah, O., & Nwanne, I. D. (2018). In vitro antioxidant and antimicrobial activity of ethanolic extract of egg plant (Solanum melongena Linn) fruit. Asian Journal of Research in Medical and Pharmaceutical Sciences, 1-10.

Mejía, L. F., y Gómez, R. (2013). Comparative evaluation of total alkaloids yield for green and red fruits of Solanum pseudocapsicum L. Revista UDCA Actualidad & Divulgación Científica, 16(1), 215-222.

Miraj, S. (2016). Solanum nigrum: A review study with anti-cancer and antitumor perspective. Der Pharma Chemica, 8(17), 62-68.

Nyeem, M. A. B., Rashid, A. M. U., Nowrose, M., & Hossain, M. A. (2017). Solanum nigrum (Maku): A review of pharmacological activities and clinical effects. IJAR, 3(1), 12-17. Disponible:https://pdfs.semanticscholar.org/b2a7/6c2850509d27d7de4cb234b3cb380e694afd.pdf [Consulta: 2020, Febrero 10].

Opande, G. T., Musyimi, D. M., Cherono, K. L., Jiveri, B. K., & Buyela, D. K. (2017). Antimicrobial activities of crude leaf extract of Solanum nigrum on Fusarium oxysporum and Pseudomonas syringae cultures in Maseno (Kenya).

Parveen, F. S., Ahmed, K., Siddiqui, M. A., Quamri, M. A., Doni, M., & Baig, S. (2019). Solanum nigrum (MAKO) with Dynamic Therapeutic Role and Pharmacological Actions: A Review. Research and Reviews: A Journal of Unani, Siddha and Homeopathy, 6(2), 18-23.

Quintana A., R. F. (2012). Estudio de plantas medicinales usadas en la comunidad indígena Tikuna del alto Amazonas, Macedonia. Nova, 10(18), 181-193.

Rahman, H. U., Mahmood, R., Haris, M., & Rahman, N. (2014). Phytochemical profiling of successive extracts of fruit and stem bark of Solanum pubescens. International Journal of Pharmacy and Pharmaceutical Sciences, 6(9), 147-153.

Rani, Y. S., Reddy, V. J., Basha, S. J., Koshma, M., Hanumanthu, G., & Swaroopa, P. (2017). A review on Solanum nigrum. World J. Pharm. Pharm. Sci, 6, 293-303.

Ravi, V., Mohamed Saleem, T. S., Patel, S. S., Raamamurthy, J., & Gauthaman, K. (2009a). Anti-inflammatory effect of methanolic extract of Solanum nigrum Linn berries. International Journal of Applied Research in Natural Products, 2(2), 33-36.

Ravi, V., Saleem, T. S. M., Maiti, P. P., Gauthaman, K., & Ramamurthy, J. (2009b). Phytochemical and pharmacological evaluation of Solanum nigrum Linn. African Journal of Pharmacy and Pharmacology, 3(9), 454-457.

Saleem, T. M., Chetty, C., Ramkanth, S., Alagusundaram, M., Gnanaprakash, K., Rajan, V. T., & Angalaparameswari, S. (2009). Solanum nigrum Linn.-A review. Pharmacognosy reviews, 3(6), 342.

Saptarini, N. M., & Herawati, I. E. (2019). The colorimetric method for determination of total Alkaloids and Flavonoids content in Indonesian black nightshade. Journal of Advanced Pharmacy Education & Research| Jul-Sep, 9(3), 81.

Schuster, A. K., Harder, B. C., Schlichtenbrede, F. C., Jarczok, M. N., & Tesarz, J. (2016). Valacyclovir versus acyclovir for the treatment of herpes zoster ophthalmicus in immunocompetent patients. Cochrane Database of Systematic Reviews, (11). Disponible:https://doi.org/10.1002/14651858.CD011503.pub2 [Consulta: 2020, Enero 15].

Sengottaiyan, A., Praburaman, L., Manoharan, K., Rajinikanth, R., Govarthanan, M., & Selvankumar, T. (2012). Hypoglycemic and hypolipidemic activity of Solanum nigrum in alloxan induced diabetic albino rats. International Journal of Pharmaceutical Sciences and Research, 3(8), 2841.

Shahiladevi, S., & Jegadeesan, M. (2017). Antimicrobial activity of black fruit variant of Solanum nigrum L. Int. J. Curr. Microbiol. App. Sci, 6(6), 2706-2713. Disponible: https://doi.org/10.20546/ijcmas.2017.605.303 [Consulta: 2020, Febrero 20].

Subash, K. R., Ramesh, K. S., Charian, B. V., Britto, F., Rao, N. J., & Vijaykumar, S. (2011). Study of hepatoprotective activity of Solanum nigrum and Cichorium intybus. Int J Pharmacol, 7(4), 504-509.

Suganya, S., Nandagopal, B., & Anbarasu, A. (2017). Natural Inhibitors of HMG-CoA Reductase—An Insilico Approach Through Molecular Docking and Simulation Studies. Journal of cellular biochemistry, 118(1), 52-57.

Sugunabai, J., Jayaraj, M., Karpagam, T., & Varalakshmi, B. (2014). Antidiabetic efficiency of Moringa oleifera and Solanum nigrum. Int J Pharm Pharm Sci, 6(Suppl 1), 40-2.

Yuvaraj, C., Kumar P., Chinnappa H., & Shukla V. J. (2013). Pharmacognostic and phytochemical investigation of root of Solanum nigrum Linn.: An ethnomedicinally important herb. International Journal of Green Pharmacy (IJGP), 7(1).

Zaghlool, S. S., Abo-Seif, A. A., Rabeh, M. A., Abdelmohsen, U. R., & Messiha, B. A. (2019). Gastro-Protective and Anti-Oxidant Potential of Althaea officinalis and Solanum nigrum on Pyloric Ligation/Indomethacin-Induced Ulceration in Rats. Antioxidants, 8(11), 512. Disponible: https://doi.org/10.3390/antiox8110512[Consulta: 2020, Febrero 19].

Zaidi, S. K., Ansari, S. A., Tabrez, S., Naseer, M. I., Shahwan, M. J., Banu, N., & Al-Qahtani, M. H. (2019). Antioxidant potential of Solanum nigrum aqueous leaves extract in modulating restraint stress-induced changes in rat’s liver. Journal of pharmacy & bioallied sciences, 11(1), 60. https://dx.doi.org/10.4103%2Fjpbs.JPBS_58_18[Consulta: 2020, Enero 15].

Zank, S., & Hanazaki, N. (2017). The coexistence of traditional medicine and biomedicine: A study with local health experts in two Brazilian regions. PloS one, 12(4).

Zebish, A., Virginia, P., Pallavi, S., & Manisha, P. (2019). Utilization of Moringa oleifera and Solanum nigrum leaves for the prepararation of value added pasta. The Allahabad Farmer, 75(1).

Published

2020-10-06

How to Cite

Tafur, V., Tello, E. G., Torres Rodríguez, D., García Orellana, Y., & Brito Borges, J. (2020). Medicinal use of Solanun nigrum and its relationship to the presence of secondary metabolites. Agroindustria, Sociedad Y Ambiente, 1(14), 158-176. Retrieved from https://revistas.uclave.org/index.php/asa/article/view/2837